USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: GLSK_HUMAN USC-OGP 2-DE database:  GLSK_HUMAN GLSK_HUMAN General information about the entry View entry in simple text format Entry name GLSK_HUMAN Primary accession number O94925 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Glutaminase kidney isoform, mitochondrial; Short=GLS; EC=3.5.1.2; AltName: Full=K-glutaminase; AltName: Full=L-glutamine amidohydrolase; Flags: Precursor;. Gene name Name=GLS Synonyms=GLS1, KIAA0838 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1148: pI=6.34; Mw=55360 Cross-references UniProtKB/Swiss-Prot O94925; GLSK_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name GLSK_HUMAN Primary accession number O94925 Secondary accession number(s) Q9UL05 Q9UL06 Q9UL07 Q9UN40 Sequence was last modified on  May 1, 1999 (version 1) Annotations were last modified on  March 15, 2017 (version 172) Name and origin of the protein Description RecName: Full=Glutaminase kidney isoform, mitochondrial; Short=GLS; EC=3.5.1.2; AltName: Full=K-glutaminase; AltName: Full=L-glutamine amidohydrolase; Flags: Precursor; Gene name Name=GLS Synonyms=GLS1, KIAA0838 Encoded on Name=GLS; Synonyms=GLS1, KIAA0838 Keywords 3D-structure; Acetylation; Alternative splicing; ANK repeat; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Mitochondrion; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transit peptide. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL AF158555; AAD47056.1; -; mRNA EMBL AF097492; AAF00088.1; -; mRNA EMBL AF097493; AAF00089.1; -; mRNA EMBL AF097495; AAF00090.1; -; mRNA EMBL AB020645; BAA74861.2; ALT_INIT; mRNA EMBL AF223943; AAF33825.1; -; mRNA EMBL AF327434; AAG47842.1; -; mRNA EMBL BC038507; AAH38507.2; -; mRNA EMBL AF279697; AAG17700.1; -; mRNA CCDS CCDS2308.1; -. [O94925-1]; . CCDS CCDS58744.1; -. [O94925-3]; . RefSeq NP_001243239.1; NM_001256310.1. [O94925-3]; . RefSeq NP_055720.3; NM_014905.4. [O94925-1]; . UniGene Hs.116448; -; . UniGene Hs.737608; -; . PDB 3CZD; X-ray; 2.40 A; A=221-533 PDB 3UNW; X-ray; 2.56 A; A/B/C/D=71-597 PDB 3UO9; X-ray; 2.30 A; A/B/C/D=71-597 PDB 3VOY; X-ray; 2.20 A; A=221-533 PDB 3VOZ; X-ray; 2.40 A; A=221-533 PDB 3VP0; X-ray; 2.40 A; A=221-533 PDB 3VP1; X-ray; 2.30 A; A=221-533 PDB 3VP2; X-ray; 2.70 A; A=221-533 PDB 3VP3; X-ray; 2.70 A; A=221-533 PDB 3VP4; X-ray; 2.45 A; A=221-533 PDB 4O7D; X-ray; 2.30 A; A=221-531 PDB 5D3O; X-ray; 2.79 A; A/B=72-597 PDB 5FI2; X-ray; 2.50 A; A/B/C/D=72-597 PDB 5FI6; X-ray; 2.52 A; A/B/C/D=72-597 PDB 5FI7; X-ray; 2.50 A; A/B/C/D=72-597 PDB 5HL1; X-ray; 2.40 A; A/B/C/D=72-597 PDB 5I94; X-ray; 2.98 A; A/B/C/D=72-597 PDB 5JYO; X-ray; 2.10 A; A/B/C/D/E/F/G/H=221-533 PDB 5JYP; X-ray; 2.74 A; A=221-533 PDBsum 3CZD; -; . PDBsum 3UNW; -; . PDBsum 3UO9; -; . PDBsum 3VOY; -; . PDBsum 3VOZ; -; . PDBsum 3VP0; -; . PDBsum 3VP1; -; . PDBsum 3VP2; -; . PDBsum 3VP3; -; . PDBsum 3VP4; -; . PDBsum 4O7D; -; . PDBsum 5D3O; -; . PDBsum 5FI2; -; . PDBsum 5FI6; -; . PDBsum 5FI7; -; . PDBsum 5HL1; -; . PDBsum 5I94; -; . PDBsum 5JYO; -; . PDBsum 5JYP; -; . ProteinModelPortal O94925; -; . SMR O94925; -; . BioGrid 109006; 41; . DIP DIP-50591N; -; . IntAct O94925; 3; . MINT MINT-4096121; -; . STRING 9606.ENSP00000317379; -; . BindingDB O94925; -; . ChEMBL CHEMBL2146302; -; . DrugBank DB00142; L-Glutamic Acid; . DrugBank DB00130; L-Glutamine; . GuidetoPHARMACOLOGY 2891; -; . iPTMnet O94925; -; . PhosphoSitePlus O94925; -; . SwissPalm O94925; -; . BioMuta GLS; -; . EPD O94925; -; . MaxQB O94925; -; . PaxDb O94925; -; . PeptideAtlas O94925; -; . PRIDE O94925; -; . TopDownProteomics O94925-2; -. [O94925-2]; . DNASU 2744; -; . Ensembl ENST00000320717; ENSP00000317379; ENSG00000115419. [O94925-1]; . Ensembl ENST00000338435; ENSP00000340689; ENSG00000115419. [O94925-3]; . GeneID 2744; -; . KEGG hsa:2744; -; . UCSC uc002use.4; human. [O94925-1]; . CTD 2744; -; . DisGeNET 2744; -; . GeneCards GLS; -; . H-InvDB HIX0161645; -; . HGNC HGNC:4331; GLS; . HPA HPA036223; -; . MIM 138280; gene; . neXtProt NX_O94925; -; . OpenTargets ENSG00000115419; -; . PharmGKB PA28734; -; . eggNOG KOG0506; Eukaryota; . eggNOG COG2066; LUCA; . GeneTree ENSGT00390000010463; -; . HOGENOM HOG000216891; -; . HOVERGEN HBG005856; -; . InParanoid O94925; -; . KO K01425; -; . OMA FMNKMAG; -; . OrthoDB EOG091G03YU; -; . PhylomeDB O94925; -; . TreeFam TF313359; -; . BRENDA 3.5.1.2; 2681; . Reactome R-HSA-210500; Glutamate Neurotransmitter Release Cycle; . Reactome R-HSA-5628897; TP53 Regulates Metabolic Genes; . Reactome R-HSA-70614; Amino acid synthesis and interconversion (transamination); . SABIO-RK O94925; -; . ChiTaRS GLS; human; . EvolutionaryTrace O94925; -; . GenomeRNAi 2744; -; . PRO PR:O94925; -; . Proteomes UP000005640; Chromosome 2; . Bgee ENSG00000115419; -; . CleanEx HS_GLS; -; . ExpressionAtlas O94925; baseline and differential; . Genevisible O94925; HS; . GO GO:0005829; C:cytosol; IEA:UniProtKB-SubCell; . GO GO:0005759; C:mitochondrial matrix; IBA:GO_Central; . GO GO:0005739; C:mitochondrion; IDA:UniProtKB; . GO GO:0004359; F:glutaminase activity; IDA:UniProtKB; . GO GO:0008652; P:cellular amino acid biosynthetic process; TAS:Reactome; . GO GO:0007268; P:chemical synaptic transmission; IEA:Ensembl; . GO GO:0006537; P:glutamate biosynthetic process; IDA:UniProtKB; . GO GO:0014047; P:glutamate secretion; TAS:Reactome; . GO GO:0006543; P:glutamine catabolic process; IDA:UniProtKB; . GO GO:0051289; P:protein homotetramerization; IDA:UniProtKB; . GO GO:0002087; P:regulation of respiratory gaseous exchange by neurological system process; IEA:Ensembl; . GO GO:0001967; P:suckling behavior; IEA:Ensembl; . Gene3D 1.25.40.20; -; 1; . Gene3D 3.40.710.10; -; 1; . HAMAP MF_00313; Glutaminase; 1; . InterPro IPR002110; Ankyrin_rpt; . InterPro IPR020683; Ankyrin_rpt-contain_dom; . InterPro IPR012338; Beta-lactam/transpept-like; . InterPro IPR015868; Glutaminase; . PANTHER PTHR12544; PTHR12544; 1; . Pfam PF12796; Ank_2; 1; . Pfam PF04960; Glutaminase; 1; . SMART SM00248; ANK; 2; . SUPFAM SSF48403; SSF48403; 1; . SUPFAM SSF56601; SSF56601; 1; . TIGRFAMs TIGR03814; Gln_ase; 1; . PROSITE PS50297; ANK_REP_REGION; 1; . PROSITE PS50088; ANK_REPEAT; 1; .

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